ATG7 Gene Expression as a Novel Tissue Biomarker in Eosinophilic Esophagitis
نویسندگان
چکیده
منابع مشابه
Tissue remodeling in eosinophilic esophagitis.
Eosinophilic esophagitis (EoE) is a recently recognized, immune-mediated disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation. The chronic esophageal eosinophilia of EoE is associated with tissue remodeling that includes epithelial hyperplasia, subepithelial fibrosis, and hypertrophy of esophageal smooth muscle. This re...
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BACKGROUND & AIMS Gene expression profiling provides an opportunity for definitive diagnosis but has not yet been well applied to inflammatory diseases. Here we describe an approach for diagnosis of an emerging form of esophagitis, eosinophilic esophagitis (EoE), which is currently diagnosed by histology and clinical symptoms. METHODS We developed an EoE diagnostic panel (EDP) comprising a 96...
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Eosinophilic esophagitis (EoE) is an allergic disorder characterized by infiltration of the oesophagus with eosinophils. We had previously reported association of the TSLP/WDR36 locus with EoE. Here we report genome-wide significant associations at four additional loci; c11orf30 and STAT6, which have been previously associated with both atopic and autoimmune diseases, and two EoE-specific loci,...
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A 74-year-old male with a history of dysphagia for 3 years presented with acute food impaction. Endoscopy showed a tight distal stricture with course rings at the middle third of the esophagus. Biopsies taken from the middle third of the esophagus showed marked infiltration of the intraepithelial lymphocytes mainly in a peripapillary distribution. The immunostains showed presence of CD3 and CD5...
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ciency. Diagnosis and HLA studies in a French-Canadian family. J Clin Invest 60:1061–1069, 1977. 24. Zeitz HJ, Miller GW, Lint TF, et al. Deficiency of C7 with systemic lupus erythematosus: Solubilization of immune complexes in complement-deficient sera. Arthritis Rheum 24:87–93, 1981. 25. Alcalay M, Bontoux D, Peltier A, et al. C7 deficiency, abnormal platelet aggregation, and rheumatoid arthr...
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ژورنال
عنوان ژورنال: American Journal of Gastroenterology
سال: 2016
ISSN: 0002-9270
DOI: 10.1038/ajg.2015.404